A Cancer Prevented, Does Not Need to be Cured.

“About half of the cancers could be prevented by applying the knowledge that we currently have…Prevention is the key”

Dr. Christopher Wild, Director, (WHO International Agency for Research on Cancer (IARC))

Read the medically-documented story of how a senior medical researcher’s diagnosis of aggressive, advanced, inoperable cancer drove him to intensive research of tens of thousands of published university studies and applying this available knowledge has left him cancer free more than a decade later. A cancer cure?

The evidence shows successful prevention may now be as simple as a small change to your diet.

Dr David Kerr, Professor of Cancer Medicine at the University of Oxford in the United Kingdom, a senior member of the medical establishment in the UK, recently referred to a paper published in the British Journal of Cancer in which the authors, a group from Queen Mary’s University of London concluded that in the UK, one in two of us will develop cancer at some stage in our lives.

Dr Kerr continued, “What a remarkable statement. People of my generation have a 1 in 2 lifetime risk of developing cancer. How can we respond to this ever increasing cancer burden? How do we make ourselves ready?

For me, most important is the message for citizens that the health services can only do so much to deal with the cancer once it has appeared, but we citizens need to take more responsibility for our own health. That means adopting lifestyle changes around diet and exercise”.

Dr David Hunter, Vincent L. Gregory Professor of Cancer Prevention and Dean for Academic Affairs at Harvard’s T.H. Chan School of Public Health recently said, “While it’s important to develop new therapies to treat cancer, it’s just as important to make progress in cancer prevention. Treatments are of course, of paramount importance to anyone diagnosed with cancer, but from a national or global perspective, there should be more investment in preventing cancer.

The continued and necessary focus on improving the treatment of cancer, and the dazzling science behind this, should not blind us to the potential for cancer prevention.”

AGGRESSIVE, INOPERABLE CANCER DIAGNOSIS

In 2004 following a routine blood test, Dr.Maxwell Strong a semi-retired medical researcher and consultant to several local and international pharmaceutical companies, returned an incredibly high PSA reading of 250 ng/ml. This was followed quickly with several biopsies and pathological examination of the cancer cells revealed a Gleeson score 4+4=8, indicative of an aggressive infiltrating carcinoma, and every reason to believe presence of metastatic disease involving bony or lymph node sites beyond the prostate gland.

Dr Edward Korbel consultant urologist indicated surgery was not an option, and radiation therapy too, was not a consideration. However, Professor John Kearsley then of the Cancer Centre, St.George District Hospital, against his better judgment (“I would prefer not to offer a course of external beam radiotherapy, given his grossly elevated PSA level”). However after further representations Professor Kearsley finally agreed although reluctantly, to provide a course of radiotherapy of 66Gy to the 95% isodose line in 35 daily fractions between 18.5.2004 and 9.7.2004.

Androgen deprivation medication was provided and discontinued during April 2005, and so with all medical options exhausted, Max Strong realised that any chance of survival with such a poor prognosis, was entirely dependent on intensive study of the available science.

“WE KNOW WHAT TO DO” - CANCER PREVENTION MUST BE IMPLEMENTED

The global cancer burden could be reduced right now if known cancer prevention strategies were implemented, public health experts say. “The main point we want to get across is that we know how to prevent many cancers”, Graham A. Colditz MD, PhD Niess-Gain Professor of Surgery and Deputy Director of The Institute for Public Health at Washington University, St.Louis, Missouri told Medscape Medical News recently. We know what to do, we just need the will to do it. The main point we want to get across is that we know how to prevent many can

“We have the knowledge, we’ve done the research, we know what works. Now is the time to use these resources to educate and engage the community to make healthy lifestyle changes and choices. In the past two decades, we and others have estimated that more than half of cancers could have been prevented by applying the knowledge that we already have.

The main point we want to get across is that we know how to prevent many cancers. That lack of implementation of effective cancer prevention strategies means that people are getting cancer that could be prevented, and are dying of cancer that could be prevented”, Professor Colditz emphasised.“We need increased research into how to break down barriers that keep well known strategies from being adopted” (Fran Lowry - Medscape Medical News, March 08,2017).

APPLYING THE MEDICAL SCIENCE WE ALREADY KNOW

Convinced that cancer, like most age-related chronic disease is not simply a chance result, Strong began an intense study of literally tens of thousands of published university studies, in the hope of discovering a ‘fertile ground or chronic disease pathway’ and if possible, successfully attenuating or removing one or more key mechanisms in this pathway.

Beginning with research of the hundreds of epidemiological studies, it soon became clear that those consuming the highest levels of a particular type of fibre that the body can’t digest, had significantly reduced risk of not only most cancers, but almost every leading cause of chronic morbidity and mortality as well, all following this same pathway beginning with oxidative stress about mid-life, then triggering low-grade chronic systemic inflammation and finally leading to epigenetic chromatin dysregulation.

It is significant that this relationship of high fibre (carbohydrate) and very high likelihood of fully-functional, disease-free ageing, has recently been confirmed in the major study of 1,609 adults aged 49 years and older, who were free of cancer, coronary artery disease and stroke when the study started, and followed for ten years by researchers from The University of Sydney’s Westmead Institute for Medical Research.

Lead study author Associate Professor Bamini Gopinath says the study is the first to look at the link between carbohydrate intake and successful ageing. She notes, “Out of all the variables we looked at, fibre intake – which is the type of carbohydrate (fibre) that the body can’t digest, - had the greatest impact on successful ageing, that is, reaching old age fully functional and disease free.

“Essentially, we found that those who had the highest intake of fibre had an almost 80 per cent likelihood of living a long and healthy life” Professor Gopinath explained.

NEUROLEX – SEARCHING and APPLYING THE KNOWLEDGE

For over a decade, a principal research focus of the Australian medical research company Neurolex Pty Ltd founded by Dr.Strong’s family and friends, has centred around development of drug-free, natural chemopreventive and therapeutic strategies targeting age-related chronic disease including cancer, atherosclerosis and cardiovascular disease, stroke, neurocognitive degeneration with learning and memory problems leading to dementia, type 2 diabetes, arthritis, and do on.

It was not long before it became clear in this research involving detailed study of several thousand published university studies, that a common although complex pathway exists in the development of almost all age-related disease, beginning about mid-life with chronic sub-clinical oxidative stress, triggering chronic systemic inflammation, and finally leading to epigenetic chromatin dysfunction mostly involving histone deacetylation and DNA methylation with clinical disease manifestation even occurring sometimes decades later.

As demonstrated in the Westmead Study by Professor Gopinath’s researchers and others, dietary fibre is one of the most promising candidates for a protective and preventive role in age-related chronic disease including of course, cancers.

in robust animal and human studies, there is substantial gut microbial fermentation of dietary fibre with short chain fatty acids (SCFA), primarily as acetate, propionate and butyrate produced as microbial end products (metabolites). The level and rate of fermentation of fibre varies according to the type and food source, e.g. fibre derived from grains is fermented much more slowly and less completely than from fruits and vegetables.

Optimising this fibre source to provide maximal bacterial metabolites, in particular the SCFA butyate has resulted in the 100% soluble vegetable fibre known as NEUROLEX. But why butyrate?

A growing body of robust published university animal and human studies have shown that butyrate has strong anti-tumorigenic properties which are highly selective for transformed cancer cells and not healthy cells, and these effects although complex and multifactorial are attributed to butyrate’s ability to alter epigenetic gene transcription.

Activation of the master regulator of the systemic inflammatory condition NF-kB and chronic systemic inflammation is a primary contributor to the development of not only most cancers but almost all chronic disease related to age-related morbidity and mortality. This chronic inflammation is blocked by butyrate.

THE “TITHONUS MISTAKE” - TIME FOR PREVENTIVE ACTION

Published data indicate that approximately 1 in 3 women and 1 in 2 males will have a cancer diagnosed in their lifetime and approximately 1 in 4 will die from a cancer.

Extended life expectancy from about 45 years only a few hundred years ago, to over 80 years is sadly not accompanied by healthy ageing, in fact government forecasts indicate that we have about an 80% chance of having one or more chronic disease or condition by age 65 years. Wellbeing often deteriorates for most of us after the age of 70 years.

The misleading value of addition of years without considering health is known as the “Tithonus Mistake”. In this Greek legend, Eos, the mythical goddess of the dawn fell in love with Tithonus, a mortal who like the rest of us was of course destined to die. She therefore asked Zeus to grant him immortal life, however, she forgot to ask for eternal youth (and health). Tithonus, although immortal, aged and became increasingly debilitated, fragile and suffered.

We are now facing the emergence of a ‘Tithonus generation’, with many added years, but low quality of life burdened by chronic illnesses, unless we learn the important lesson from the Westmead Study which having followed 1,609 adults for 10 years found that those whose diet was highest in fibre, had not our forecast 80% likelihood of at least one chronic disease as we age, but in fact an 80% likelihood of being fully-functional, and disease-free with ageing.

This has now been made affordable and simple with development of the optimised, safe vegetable fibre NEUROLEX. And let Dr Strong now in his very active 8th decade, attest to its use as his sole chemopreventive therapy. Twelve years on from his original cancer diagnosis, he is now cancer-free with aPSA of only 1.58 ng/ml (down from 250 ng/ml and with NEUROLEX fibre the only chemopreventive used for the last 5 years), and would be happy to discuss the impressive chemopreventive science involved with regular NEUROLEX use, and can be contacted: Mob: 0418 413657

Email: maxwellstrongresearch@gmail.com

www.neurolex.com.au

CANCER PREVENTION

NEUROLEX PTY LTD

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